This book introduces how to build an integrated simulation tool on the MATLAB platform to simulate advanced techniques at the physical layer of 5G and 6G networks, such as modulation, multiple access, energy saving technologies, massive MIMO, physical layer security, cognitive radio, and artificial intelligence. This simulation tool has a user-friendly interactive interface with usage instructions and outputs graphs to evaluate the performance of each method. The goal of the simulations is to achieve results related to performance indicators at the physical layer, such as outage probability, throughput, bit error rate or frame error rate, and security capacity. This book helps the readers learn how to build a simulation framework for evaluating advanced 5G/6G technologies by themselves and apply them to their research.